Josh Drucker is a preacher's son with a calling to the ministry. Andrew Robertson is a bouncer and construction worker with a taste for motorcycles. They never would have met, if Andrew hadn't fallen for Josh's younger sister. What starts out as an unlikely friendship becomes a deep bond, until a tragic event leads to suspicion and revenge. When the smoke clears, two people are dead ... and one is on the way to Death Row.

Growing up in a small Texas town, Misti Mayo and Christine Smith share everything: clothes, music, even teen pregnancy. But a move to the big city introduces them to a new lifestyle and a new group of friends. They find themselves in a spiral of bad decisions and escalating violence. With their backs against the wall, each of the girls has to choose between herself... and her best friend.

Butch Pratt and Ed Swiger meet as freshmen at an idyllic college campus in western Pennsylvania. They're fast friends, fraternity brothers, and ultimately college roommates. Both are on the way to postgraduate studies and glowing careers. But a botched prank against their own fraternity suddenly puts the law on their tails. And with their futures at stake, one of them decides that success is worth killing for.

Can we ever escape our past? An organic farmer (Patrick Drum) meets a lumber mill worker (Gary Blanton) in Washington’s Olympic Peninsula. They become close friends, and when Gary has to move out of his house, Patrick invites him to share his cabin in the woods. But one of them is hiding a dark secret. And when the other finds out, it begins a spiral of anger and vengeance… leading to a killing spree and an intensive manhunt. With two bodies already found, police race to find the suspect before he kills again.

When two young mothers meet by accident, they seem destined to become best friends. Jamie Dennis is an aspiring writer who spends hours honing her craft. Anne Camp loves playing with Jamie’s children, and she offers to be their babysitter. But this friendship is heading for trouble. Jamie has money problems and needs a quick way to pay the bills. Anne is in a bitter custody battle for her own daughter. Both women will have to make a terrible choice: to save your family, would you sacrifice your best friend?

Dean Allen is a clean-cut carpenter in east Texas, a young man who always follows the rules. Dean befriends a newcomer, Robert Pogue, a butcher who never met a rule he couldn’t break. Dean is drawn to Robert’s fun-loving nature, and the two become best friends. Although only 17, Dean meets and marries Janice, who is five years his senior. But when Janice begins an affair with Robert, the two best friends turn on each other–a showdown that will end in gruesome death.

Lula Young and Linda Leedom seem like typical moms. They live on a quiet suburban street, raising their families side by side. Lula is a homemaker who volunteers at the fire department, and Linda is a former nurse with a home business as an accountant. Through sickness and heartbreak, Lula and Linda are best friends and perfect neighbors. But looks can be deceiving. To make her dreams come true, one of them will do anything: fraud, arson… even murder.

Whoever said there's honor among thieves... never met this group of best friends. Michael Falco, Gary Evans, and Tim Rysedorph all come from working-class South Troy, NY. Friends since childhood, they dream of careers in music and the arts. But to survive in this Rust Belt town, they turn to small-time criminal activity. As the crimes get bigger, so do the stakes. The police are closing in, and one of them turns on his friends, murdering them one by one. Can he be stopped before he kills them all?

Alabama party boys and best friends Butch Hampel and Richard Terry meet while working at the local paper mill. The two are inseparable bachelors and roommates living the good life, until a woman comes between them. When one best friend falls for the other man's wife, all bets are off. It's a violation of an age-old code, a code their friends call "Dude Law." But will this be a crime of passion, or a crime of jealousy?

Gerry Scotti and Barry Feldman are living the good life in Los Angeles. Gerry is a high-powered defense attorney, Barry his brilliant paralegal. They become best friends, each complementing the other's strengths and weaknesses. But there's a dark side to their work, defending drug dealers and other accused criminals. And Barry has a problem, a gambling addiction that already landed him in jail. As the stakes get higher, one of them will do anything to avoid losing it all.

At a school for at-risk youth in Illinois, Sarah Kolb rules the hallways. She takes new student Adrianne Reynolds under her wing, showing her the ropes and introducing her to the popular crowd. As the two get closer and closer, people around them start to wonder if they're more than best friends. But in this school, only one of them can be the most popular. Jealousy leads to contempt, and rumors spread like wildfire... until a final showdown after class turns into a deadly confrontation.

Can guys and girls ever really be best friends? It's a question Alphonze Fitzhugh and Britani Coberly hear many times--and they always shrug it off. These Northern California teenagers are more like brother and sister, sharing a passion for sports and meeting up with their friends for bonfires in the local vineyards. But like a grape that isn't picked, this friendship withers on the vine. Hidden attraction turns into jealousy, which then sets off a chain reaction of anger and revenge.

When retired rodeo champion Bob Huber takes a young, aspiring cowboy named Ryan Bryant under his wing, it seems like a perfect match. The two start running a business and coaching a little league team. Yet slowly but surely, one man begins to chafe under the yoke of their friendship and hatches a plan to rid himself of the other ... forever. In a ruthless competition between the wily older man and the strong young buck, who will win?

When LA native Stephen Eldridge needs a new place to live, he turns to his best friend, Miki McDermott. Stephen and Miki have a lot in common. Both are gay, single, and outgoing, and both come from big, loving families. Stephen runs his own landscaping business, and Miki is a respected nurse. But what starts out as a simple living arrangement soon gets complicated. After they sign an insurance policy on the mortgage, one of them decides that in this house, two is a crowd.

At the world's top university for the Deaf and hard of hearing, college freshmen Eric Plunkett and Joseph Mesa live across the hall from each other. Eric is an outgoing film buff with a preference for horror movies... Joseph, a talented athlete from the island paradise of Guam. But for one young man, the pressures of college will be too much. The secret he's been hiding will drive him to kill... and no one will hear his victims' screams.

A chance encounter during a coming-of-age summer brings teenagers Michelle Jensen and Jason Means together. Meeting on a camping trip, they seem to come from different worlds. Michelle has a stable, church-going family, while Jason has a more troubled background. But both are hoping to walk in the other's shoes. It's a summer of first love, exploration, and heartbreak--only to end in a terrible, senseless murder on a dark Iowa road.

Any time best friends turn on each other, it's a tragedy--years of love and trust swept away in a moment of anger, jealousy, or greed. But some cases are so shocking that nobody sees them coming. These are the seven least likely suspects from Season One of I Killed My BFF. Narrated in the voice of murder victim Misti Mayo, this special episode traces the stories of seven killers who fooled everyone... until it was too late.

Two West Virginia girls, best friends since third grade, turn on each other when a third girl transforms their solid duo into an unstable trio. When one of the girls goes missing, police focus in on her BFF and eventually prove that she's the killer.

He was from the wrong side of the tracks, she was the apple of her parents' eye and had every advantage in life. Together they became unlikely best friends, until another girl, and a secret, come between them. Police in Arizona bear down on one of the BFFs until the truth comes out and the gruesome murder is solved.

Two girls in Pennsylvania grow up the best of friends, but things get rocky when they take the next step and become lovers. Add a third girl to the mix, and this relationship turns downright toxic. One of the girls ends up dead, and the other is sent to prison for the rest of her life.

A dead-broke Florida man wins a $30 million lottery, and everyone he knows comes after him for a handout. He turns to his best friend to help him manage his money, but that's when things went sideways for these BFFs.

Two best friends, steeped in the California “goth” culture are split apart by a dark, charismatic teen who holds sway over both of them. The teens’ obsession with the dark side goes too far, and one of the BFFs is murdered in what police call a “senseless thrill kill.”

In a sleepy Ohio town, two young girls find each other on line. Their friendship blossoms and then becomes something deeper. But when one of the girls hooks up with someone new, things take a dark turn and police have a murder to solve.

Two rough and tumble guys grow up in rural Michigan. They bond over their shared love of cars, women, and beer. But when a woman comes between them, these two BFFS turn on each other and the result is deadly.

A former deejay living in California, inherits money from his wealthy father. The heir’s BFF, a banker, offers to help him manage the windfall, but the two have a falling out that ends up with a showdown, a murder and a manhunt.